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A fatalistic car crash in Mexico city sets off a chain of events in the lives of three people: a supermodel, a young man wanting to run off with his sister-in-law, and a homeless man. Their lives are catapulted into unforeseen situations instigated by the seemingly inconsequential destiny of a dog.
Cielo is a mother whose teenage daughter is kidnapped in Northern Mexico. When the authorities offer no support in the search, Cielo takes matters into her own hands and transforms from housewife into a vengeful militant.
The husbands of a charismatic nurse devise a plan to free her from prison when she is arrested for being a polygamist.
The First Lady of Mexico has big plans to improve conditions for the country. As she starts to lose faith in her husband, President Diego Nava, she finds herself at a crossroad where she will need to find a way to deal with a great challenge.