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Several years after the murderous events of the first movie left her father dead, Emma is now living with her aunt Angela and navigating high school. Angela’s husband begins to suspect that Emma may not be as innocent as she appears and suggests sending her off to boarding school. Meanwhile, a new girl at school seems to know Emma’s secrets, leaving Emma no choice but to slip back to her old ways and take care of her enemies by any means necessary.
When Charlie Harris ends up in a coma, he leaves the Hope-Zion Hospital in chaos - and his fiancée and fellow surgeon, Alex Reid, in a state of shock. As the staff of Hope-Zion races to save lives, comatose Dr. Harris wanders the halls of Hope-Zee in "spirit" form, not sure if he's a ghost or a figment of his own imagination.