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Woody, Buzz, and the rest of Andy's toys haven't been played with in years. With Andy about to go to college, the gang find themselves accidentally left at a nefarious day care center. The toys must band together to escape and return home to Andy.
Henry is a player skilled at seducing women. But when this veterinarian meets Lucy, a girl with a quirky problem when it comes to total recall, he realizes it's possible to fall in love all over again…and again, and again. That's because the delightful Lucy has no short-term memory, so Henry must woo her day after day until he finally sweeps her off her feet.
While in his teens, Donny fathered a son, Todd, and raised him as a single parent up until Todd's 18th birthday. Now, after not seeing each other for years, Todd's world comes crashing down when Donny resurfaces just before Todd's wedding.
The toys throw Ken and Barbie a Hawaiian vacation in Bonnie's room.
To climb the corporate ladder to success, a businessman agrees to coach his company's all-girl soccer team with the help of his secret weapon: his fiancee's son.
Unlucky in love, chemist Paul Matthews visits gypsy Madame Rosa for help. Quickly realizing he is a hopeless nerd, she gifts him with Love Potion No. 8, which makes anyone who wears it irresistible to the opposite sex for four hours. Paul and animal psychologist coworker Diane Farrow decide to test it on themselves. The awkward pair suddenly find themselves alluring to anyone they approach, but soon realize they are most attracted to each other.
Davey Stone, a 33-year old party animal, finds himself in trouble with the law after his wild ways go too far.
Bobby Boucher is a water boy for a struggling college football team. The coach discovers Boucher's hidden rage makes him a tackling machine whose bone-crushing power might vault his team into the playoffs.
With the ratings dropping for a wilderness-themed TV show, two animal fans go to the Andes in search of Bigfoot.