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Ten years after the first American Pie movie, three new hapless virgins discover the Bible hidden in the school library at East Great Falls High. Unfortunately for them, the book is ruined, and with incomplete advice, the Bible leads them on a hilarious journey to lose their virginity.
When he is betrayed by a trusted friend, Mathayus must marshal all his strength and cunning to outwit a formidable opponent who will stop at nothing to unlock a supreme ancient power.
A young campaign aide gets in way over his head when he sleeps with the wife of a presidential candidate, sending him into a downward spiral of corruption and blackmail.
