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An ordinary senior high school girl named Mika meets Hiro, a showy boy with dyed hair and pierced ears. It is a "pure love" story of the two going through many unimaginably sad incidents while nurturing their love single-mindedly. It not only depicts the first love of the senior high school couple but also weaves "a story of Mika and Hiro" through episodes probably familiar to anybody, such as warmth and affection of their family members supporting the two, importance of living, interactions with friends, and so on.
A brain surgeon named Minakata Jin has spent the last two years in anguish, as his fiancee lies in a vegetative state after an operation he performed. One day, he faints at the hospital and awakens to find himself transported back in time to the Edo period. He is soon attacked by a samurai, but he escapes with the help of a man named Kyotaro. Kyotaro suffers a serious injury to the head while trying to protect him, but Jin manages to save his life despite a lack of proper medical equipment. Because of that, Kyotaro's sister Saki begins taking an interest in Jin and becomes his assistant. Meanwhile, Jin is determined to find a way back to the present.