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Heroin addict Mark Renton stumbles through bad ideas and sobriety attempts with his unreliable friends -- Sick Boy, Begbie, Spud and Tommy. He also has an underage girlfriend, Diane, along for the ride. After cleaning up and moving from Edinburgh to London, Mark finds he can't escape the life he left behind when Begbie shows up at his front door on the lam, and a scheming Sick Boy follows.
The inhabitants of the British Isles have lost their battle against the onslaught of disease, as the deadly rage virus has killed every citizen there. Six months later, a group of Americans dare to set foot on the isles, convinced the danger has come and gone. But it soon becomes all too clear that the scourge continues to live, waiting to pounce on its next victims.
Twenty-something Richard travels to Thailand and finds himself in possession of a strange map. Rumours state that it leads to a solitary beach paradise, a tropical bliss - excited and intrigued, he sets out to find it.
When David, Juliet, and Alex are searching for a fourth roommate for their flat, they settle on the aloof Hugo. However, they soon find Hugo dead, with a large sum of cash being among his belongings. The three friends decide to keep the money, dismembering and burying Hugo's body. However, their newfound fortune begins to corrode their friendships, with each roommate resorting to manipulation tactics to scam the others out of the money.
A couple of angels, O'Reilly and Jackson, are sent to Earth to make sure that their next supervised love-connection succeeds. They follow Celine, a spoiled rich girl who has just accidentally shot a suitor and, due to a misunderstanding, is kidnapped by janitor Robert. Although Celine quickly frees herself, she stays with Robert for thrills. O'Reilly and Jackson pursue, hoping to unite the prospective lovers.