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In Japan, the daycare teacher Kyoko Okudera is convinced by her colleague and friend Madoka to visit her boyfriend Naoto Sakurai in the restaurant where he works instead of studying as planned. When the owner Mr. Wang answers his daughter's mobile phone, he receives a message telling him that he would die in an accident in the kitchen. This immediately comes true
Hideo Suzuki is a 35-year-old mangaka assistant, whose life seem to be stuck around his exhausting but low-paying job, unfulfilled dreams, strange hallucinations and unsatisfying relationships. He sees himself as a supporting character in his own life, has low self-esteem, resulting in frustration. One day, the world as Hideo knows it is shattered by the presence of a disease that turns people into homicidal maniacs, whose first instinct is to attack and devour the nearest human.
A brain surgeon named Minakata Jin has spent the last two years in anguish, as his fiancee lies in a vegetative state after an operation he performed. One day, he faints at the hospital and awakens to find himself transported back in time to the Edo period. He is soon attacked by a samurai, but he escapes with the help of a man named Kyotaro. Kyotaro suffers a serious injury to the head while trying to protect him, but Jin manages to save his life despite a lack of proper medical equipment. Because of that, Kyotaro's sister Saki begins taking an interest in Jin and becomes his assistant. Meanwhile, Jin is determined to find a way back to the present.
