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FBI agent Malcolm Turner goes back undercover as Big Momma, a slick-talking, slam-dunking Southern granny with attitude to spare! Now this granny must play nanny to three dysfunctional upper class kids in order to spy on their computer hacked dad.
When a street-smart FBI agent is sent to Georgia to protect a beautiful single mother and her son from an escaped convict, he is forced to impersonate a crass Southern granny known as Big Momma in order to remain incognito.
Another young boy with 'hoop dreams' finds an old pair of Michael Jordan's sneakers and can suddenly play ball like the greatest player in the world.
Three pairs of friends relationships go from good to bad and back again. Several couple fall out over girls, boys and work. Can all these couples settle their differences and be friends again?
Ben Gideon, a doctor of great skill and with a great bedside manner, heads the experimental oncology ward at a fictional teaching hospital in New England. Based on the work of Dr. Jerome Groupman, Gideon fights to inspire the next generation of doctors.