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Once again tampering with mother nature to disastrous results, Dr. Herbert West continues his research while serving time in a maximum security prison for his previous exploits. West's limited prison-cell experiments are suddenly interrupted by the arrival of a new prison doctor and the brother of the girl who suffered from West's experiments 13 years earlier.
In a fantasy world of opposing kingdoms, a 15-year old girl must find the fabled MirrorMask in order to save the kingdom and get home.