When larcenous real estate clerk Marion Crane goes on the lam with a wad of cash and hopes of starting a new life, she ends up at the notorious Bates Motel, where manager Norman Bates cares for his housebound mother.

There's a deficit of good, honest women in the West, and Roy Whitman wants to change that. His solution is to bring a caravan of over 100 mail-order brides from Chicago to California. It will be a long, difficult and dangerous journey for the women. So Whitman hires hardened, cynical Buck Wyatt to be their guide across the inhospitable frontier. But as disaster strikes on the trail, Buck just might discover that these women are stronger than he thinks.

What can two little mice possibly do to save an orphan girl who's fallen into evil hands? With a little cooperation and faith in oneself, anything is possible! As members of the mouse-run International Rescue Aid Society, Bernard and Miss Bianca respond to orphan Penny's call for help. The two mice search for clues with the help of an old cat named Rufus.

The living Volkswagen Beetle helps an old lady protect her home from a corrupt developer.

Lin McAdam rides into town on the trail of Dutch Henry Brown, only to find himself in a shooting competition against him. McAdam wins the prize, a one-in-a-thousand Winchester rifle, but Dutch steals it and leaves town. McAdam follows, intent on settling his old quarrel, while the rifle keeps changing hands and touching a number of lives.

When hedonistic but charming con man Elmer Gantry meets the beautiful Sister Sharon Falconer, a roadside revivalist, he feigns piousness to join her act as a passionate preacher. The two make a successful onstage pair, and their chemistry extends to romance. Both the show and their relationship are threatened, however, when one of Gantry's ex-lovers decides that she has a score to settle with the charismatic performer.

A petty crook moves to an Ohio town and courts a factory owner's disabled daughter.

During the Klondike Gold Rush, a misanthropic cattle driver and his talkative elderly partner run afoul of the law in Alaska and are forced to work for a saloon owner to take her supplies into a newly booming but lawless Candian town.

Recently paroled from prison, legendary burglar "Doc" Riedenschneider, with funding from Alonzo Emmerich, a crooked lawyer, gathers a small group of veteran criminals together in the Midwest for a big jewel heist.

Scott Turner has 3 days left in the local police department before he moves to a bigger city to get some 'real' cases—not just misdemeanors. When Amos Reed is murdered, Scott sets himself on the case, but the closest thing to a witness to the murder is Reed's dog, Hooch, which Scott has to take care of—to avoid Hooch being 'put to sleep'.

The series initially starred veteran movie supporting actor Ward Bond as the wagon master, later replaced upon his death by John McIntire, and Robert Horton as the scout, subsequently replaced by lookalike Robert Fuller a year after Horton had decided to leave the series. The series was inspired by the 1950 film Wagon Master directed by John Ford and starring Ben Johnson, Harry Carey Jr. and Ward Bond, and harkens back to the early widescreen wagon train epic The Big Trail starring John Wayne and featuring Bond in his first major screen appearance playing a supporting role. Horton's buckskin outfit as the scout in the first season of the television series resembles Wayne's, who also played the wagon train's scout in the earlier film.