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A criminal psychologist loses his arm in a car crash, and becomes one of three patients to have their missing limbs replaced by those belonging to an executed serial killer. One of them dies violently, and disturbing occurrences start happening to the surviving two.
Presented by Walsh, the show profiles and assist law enforcement in the apprehension of fugitives wanted for numerous crimes, including murder, rape, kidnapping, child molestation, white-collar crime, organized crime, armed robbery, gang violence, and terrorism, and also many of whom are currently on the FBI Ten Most Wanted Fugitives list.
Victims' rights activist John Walsh and his son, Callahan, showcase time-sensitive, unsolved cases in desperate need of attention, mobilizing the public to engage in the pursuit of justice.