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Laura has been with Antonio all her life and, just when she begins to wonder if that is really the life she wants, Sergio and Siena cross paths in their lives. Sergio is a former high school classmate and Siena, his millennial girlfriend who arrives to revolutionize everyone's lives. Laura, Raquel and Cris, close friends for years, convince their respective husbands to play a game that Siena proposes to them: the game of keys. The game consists of everyone putting their keys in a bowl. At random, each one chooses some keys and he must go to spend the night with the owner of the keys. This game will revolutionize the group of friends and their lives. It will make them discover who they are and what they really want.
A young man is stood up at the altar. His overprotective mother decides to join him is what would have been his honeymoon, so as not to waste the trip. He ails while his mum enjoys the trip of her life.
Enrique Hubermann, homeopathic physician, travels in flight from a love. By a joke of fate, in that distant place he meets the woman he wants to forget, a beautiful young woman like a demon who manipulates men and triggers dangerous passions.
Five sisters must take care of a hotel for a year after their father's death in order to get the 6 million dollar inheritance he left them.