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Gu Jue Zhuan follows Shang Gu, once a leader of the four immortals, who falls into a deep sleep after sacrificing herself in a trial that lasted 60,000 years. Shang Gu wakes up many years later, and memories of what happened 300 years ago were completely wiped. But her former lover, Bai Jue, never forgot about her. Sacrificing his reincarnation for her life, he waited for her for 60,000 years. Even when his soul disappears, Shang Gu will wait for him forever. Gu Jue Zhuan, previously known as Shang Gu, was first announced in 2014, but was stuck in production hell. Its based on the xianxia novel of the same name by Xing Ling (星零), first published in 2012.
Ren Xinzheng, a professor at the University of Traditional Chinese Medicine, is dedicated to spreading Chinese medicine. He resigned to set up a traditional Chinese medicine inheritance class, hoping to train successors who can truly pass on the way of Chinese medicine. Unscrupulous Sun Toutou also accidentally joined the mentoring class, and he was at odds with Ren Xinzheng's son Ren Tianzhen, Yang Xiaohong, who had changed his career as a lawyer, Peng Shiyan, a pediatrician at a tertiary hospital, and Zhao Liquan, who wanted to become a famous doctor with the expectation of the whole village, and other students were also incompatible.
Yu Qing Luo gives birth to a son named Nan Nan. Seven years later, she becomes a renowned physician with unorthodox skills. She sets out to find Yang Xiu Cheng, Nan Nan's father. On her journey, she comes across a man named Ye Xiu Du, the prince of Feng Cang Kingdom. As Ye Xiu Du resembles Yang Xiu Cheng, Yu Qing Luo grew to resent him. However after several encounters, she realizes it was just a co-incidence and began to open up to him. At the same time, Yu Qing Luo's skills and talent attracted unwanted attention and she gets swept up in conflicts. Yu Qing Luo and Ye Xiu Du work together to defeat the opponents.
