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A young neurosurgeon inherits the castle of his grandfather, the famous Dr. Victor von Frankenstein. In the castle he finds a funny hunchback, a pretty lab assistant and the elderly housekeeper. Young Frankenstein believes that the work of his grandfather was delusional, but when he discovers the book where the mad doctor described his reanimation experiment, he suddenly changes his mind.
After spending decades living in the shadow of his more famous and successful sibling, Consulting Detective Sigerson Holmes (Wilder) is called upon to help solve a crucial case that leads him on a hilarious trail of false identities, stolen documents, secret codes... and exposed backsides.