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The story follows a Roman architect named Lucius, who is having trouble coming up with ideas. One day, he discovers a hidden tunnel underneath a spa that leads him to a modern Japanese bath house. Inspired by the innovations found there, he creates his own spa, Roma Thermae, bringing in the modern ideas to his time.
The Team Rocket leader, Giovanni, has found Mewtwo in a remote area of the Johto region. As Giovanni tries to re-capture Mewtwo, Ash and his friends are kidnapped by Domino, a new Team Rocket member, while trying to rescue Pikachu from Jessie and James. The Clone Pokemon are also captured and are then used as bait for Mewtwo. The situation then becomes a battle between the wills of Mewtwo and Giovanni; and Mewtwo also tries to discover if it and the clones have a purpose in life, even though they are products of science.
The devious leader of Team Rocket Organization, Giovanni, has a fervent ambition to take control of the Pokémon world through both financial and military means. To achieve his military needs, he covets a Pokémon stronger and more adept than any other, a veritable living war weapon, so he enlists a scientist named Doctor Fuji to create this being from the DNA of the ancestor of all Pokémon and most powerful of Pokémon, Mew, which Fuji had found on a previous jungle expedition. Fuji accepts, for he is heavily into the prospect of cloning to create and restore life itself, because of his love for his deceased daughter, Amber.
Rei Kagami (Ryosuke Yamada) is a billionaire and the CEO of the leading conglomerate company Kagami Group. He is an extremely smart inventor, who has developed revolutionary products, and is now doing research on high precision AI. When he was little, he was a curious and kind kid. As he grew up, his curiosity remained, but he became self-centered. For certain reasons, he begins to teach at a school, while hiding his identity as a billionaire and the CEO of Kagami Group. His performance as a teacher is quite poor compared to his excellent work as a CEO. He is incapable of understanding the ordinary lives of the teachers and students around him.