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A young woman encounters a malevolent supernatural force while searching for her missing sister in Tokyo, a mean high school prank goes horribly wrong, and strange things begin happening in a Chicago apartment building.
Creatures, bound by the blood of the wolf, that can kill with curses and move at lightening speed, watching the night sky for the rise of the blood-red crescent moon. They are SKINWALKERS. They feed on our flesh and thirst for the taste of human blood. The red moon signals each pack, divided by principles, hell bent to survive an ancient prophecy.
Geeky 14-year old Ethan is left to babysit his younger sister, Jane, with his best friend Benny but after Ethan inadvertently puts Jane in harm's way, his parents hire a professional babysitter, the beautiful yet mysterious 17-year-old Sarah who, unbeknownst to them, is actually a fledgling vampire.
Jake Kimble, the sole survivor of the Chicago massacre, is killed while in solitary confinement. His doctor begins investigating the claims he made about a long-haired woman in white, as a mysterious Japanese woman arrives at his old apartment building to help them get rid of the curse.
Ethan, Benny and fledgling vampire Sarah battle zombies, demons and the other supernatural beasties that regularly threaten their school.