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A boy named George Jung grows up in a struggling family in the 1950's. His mother nags at her husband as he is trying to make a living for the family. It is finally revealed that George's father cannot make a living and the family goes bankrupt. George does not want the same thing to happen to him, and his friend Tuna, in the 1960's, suggests that he deal marijuana. He is a big hit in California in the 1960's, yet he goes to jail, where he finds out about the wonders of cocaine. As a result, when released, he gets rich by bringing cocaine to America. However, he soon pays the price.
An amusement park mogul offers a random group of diverse people $1 million to spend the night in a decrepit former mental institution.
Portland, Oregon, 1971. Bob Hughes is the charismatic leader of a peculiar quartet, formed by his wife, Dianne, and another couple, Rick and Nadine, who skillfully steal from drugstores and hospital medicine cabinets in order to appease their insatiable need for drugs. But neither fun nor luck last forever.
Solomon and Tummler are two teenagers killing time in Xenia, Ohio, a small town that has never recovered from the tornado that ravaged the community in the 1970s.
Undercover cop Jim Raynor (Jason Patric) is a seasoned veteran. His partner, Kristen Cates (Jennifer Jason Leigh), is lacking in experience, but he thinks she's tough enough to work his next case with him: a deep cover assignment to bring down the notoriously hard-to-capture drug lord Gaines (Gregg Allman). While their relationship turns romantic during the assignment, they also turn into junkies, and will have to battle their own addictions if they want to bring down Gaines once and for all.
A clairvoyant woman thinks that she's met her future husband because she's seen him in a dream. They marry and he takes her back to his butcher shop in New York city, where her powers tend to influence everyone she meets while working in the shop. Through her advice, she helps others and eventually finds the true man of her dreams.
