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After her younger sister gets involved in drugs and is severely injured by contaminated heroin, a nurse sets out on a mission of vengeance and vigilante justice, killing drug dealers, pimps, and mobsters who cross her path.
In Texas, the aspirant actress Nicole Carrow runs away home to Los Angeles with her boyfriend Jess Hilts. They drive through a shortcut in an old road, and when they park in a rest stop, Jess is abducted by the sadistic driver of an old yellow truck. Along the night, Nicole is threatened by the sick maniac, while mysterious things happen to her in the place.
