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Dr. Malcolm Sayer, a shy research physician, uses an experimental drug to "awaken" the catatonic victims of a rare disease. Leonard is the first patient to receive the controversial treatment. His awakening, filled with awe and enthusiasm, proves a rebirth for Sayer too, as the exuberant patient reveals life's simple but unutterably sweet pleasures to the introverted doctor.
A young inductee into the military is given the task of looking after some chimpanzees used in the mysterious 'Project X'. Getting to know the chimps fairly well, he begins to suspect there is more to the secret project than he is being told.