An exceptional marksman and hopeless playboy, private eye Ryo Saeba reluctantly forms an alliance with his late partner's sister to investigate his death.

After Shogo Ogami’s death in Hiroshima, Detective Shuichi Hioka successfully implemented Shogo Ogami’s plan, which was to control the yakuza to prevent further gang wars and save innocent people from getting harmed. Shuichi Hioka manages the criminal organizations, but, due to one evil person who gets released from prison, the situation drastically changes.

Upon the death of their estranged father, three sisters invite their 13-year-old half sister to live with them.

High school student Kyosuke Shikijo is the most talented member of the school's martial arts of the fist club. His late father was detective and Kyosuke share his father's strong sense of justice. Kyosuke also has a secret. Kyosuke likes to wear female underwear and transforms himself into the alter ego "Hentai Kamen," wearing female underwear and gaining superhuman powers. This unusual interest also comes from his parents, with his father a masochist and his mother a sadist. By chance, Kyosuke gets the underwear of female high school student Aiko Himeno. With her underwear, he gains various pervert techniques and attempts to protect Aiko from a dirty and heinous teacher.

News about the disappearance of panties is still being covered every day. Kyosuke still wears Aiko Completo's panties to battle evil. Meanwhile, Aiko has mixed emotions and decides to get her panties back. Kyosuke suffers from the loss of Aiko's panties and disappears, but his biggest enemy yet is about to materialise.

Saigo Takamori, the hero of the Meiji Restoration, was born to a poor, low-ranking samurai family in the Satsuma domain (present day Kagoshima Prefecture). His simple honesty caught the attention of its charismatic feudal lord of Satsuma, Shimazu Nariakira. Nariakira’s assertion that the love of people is what will enrich and strengthen the nation captivated Saigo who took on Nariakira’s secret mission and eventually became a key person for Satsuma. Not a portrait of him survives today and much of his life is a mystery. He is a man who was twice exiled and thrice married. He overthrew the Tokugawa Shogunate with exceptional bravery and action. Although he accomplished the restoration, he lost his life in a fight with the new Meiji government.

Japanese-American track star Mizuki Ashiya transfers from a school in California to Japan, but not to just any old school. The school is Osaka High School—an all male high school! Mizuki Ashiya must disguise herself as a boy, all to get closer to her hero, Izumi Sano, a high-jump athlete who attends Osaka High. Now with short hair, flattened chest, and deeper voice, Mizuki becomes roommates with Izumi Sano, but trouble soon starts to brew. Izumi Sano discovers by accident that Mizuki is a girl and falls in love with her, but Mizuki is unaware of the fact. Complicating things, fellow classmate Shuichi Nakatsu starts to develop feelings for Mizuki, unaware that she is a girl!

TOKYO MER is formed by order from the Governor of Tokyo. The name of the group stands for TOKYO Mobile Emergency Room. The members are emergency care professionals and they are to go to sites of dangerous accidents and disasters by ER car. Their ER car is a large vehicle equipped with the latest medical devices and an operating area. There, TOKYO MER saves lives of the injured. Kōta Kitami is a doctor for TOKYO MER and its leader. He holds a strong conviction that, regardless of the dangers, he will go to accident sites to save lives.