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Two Jesuit priests travel to seventeenth century Japan which has, under the Tokugawa shogunate, banned Catholicism and almost all foreign contact.
When a massive, gilled monster emerges from the deep and tears through the city, the government scrambles to save its citizens. A rag-tag team of volunteers cuts through a web of red tape to uncover the monster's weakness and its mysterious ties to a foreign superpower. But time is not on their side - the greatest catastrophe to ever befall the world is about to evolve right before their very eyes.
Schoolgirl Kuniko is kidnapped by a middle-aged man Iwazono when she is jogging. He tells her that he had a failed marriage which leaves him a deep and everlasting scar in his mind. He kidnaps her in search of a perfect marriage and intends to lock her in the room and 'educate' her to perform perfect sex where body and soul are united.
As sadomasochistic yakuza enforcer Kakihara searches for his missing boss he comes across Ichi, a repressed and psychotic killer who may be able to inflict levels of pain that Kakihara has only dreamed of.
When the son of an American man and a Japanese women is killed, the man transforms into Tetsuo.
A businessman, Tsuda, runs into a childhood friend, Kojima, on the subway. Kojima is working as a semiprofessional boxer. Tsuda soon begins to suspect that Kojima might be having an affair with his fiancée Hizuru. After an altercation, Tsuda begins training rigorously himself, leading to an extremely bloody, violent confrontation.
A "metal fetishist", driven mad by the maggots wriggling in the wound he's made to embed metal into his flesh, runs out into the night and is accidentally run down by a Japanese businessman and his girlfriend. The pair dispose of the corpse in hopes of quietly moving on with their lives. However, the businessman soon finds that he is now plagued by a vicious curse that transforms his flesh into iron.
