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The story of Henry, a stand-up comedian with a fierce sense of humour and Ann, a singer of international renown. In the spotlight, they are the perfect couple, healthy, happy, and glamourous. The birth of their first child, Annette, a mysterious girl with an exceptional destiny, will change their lives.
A space-obsessed man gets the opportunity of a lifetime thanks to a Mars colonization program but finds his plans compromised by his feelings for a woman who brings him down to Earth.
Musician Jon Batiste attempts to compose a symphony as his wife, writer Suleika Jaouad, undergoes cancer treatment.
Quinn, a neurotic man, is diagnosed with a harmless eye condition and soon after his life spirals out of control. He second-guesses his plans to propose to his longtime girlfriend, Devon, after his beautiful coworker, Kelsey, confesses that she has a crush on him. After a conversation with his best friend, Jameson, he clumsily tries to explain his doubts to Devon, but his possible proposal turns into a break-up. When Devon flees to Paris, he follows her in a last-ditch effort to win back "the one."
Physicists Leonard and Sheldon find their nerd-centric social circle with pals Howard and Raj expanding when aspiring actress Penny moves in next door.
Aspiring super-villain Dr. Horrible wants to join the Evil League of Evil and win the girl of his dreams, but his nemesis, Captain Hammer, stops him at every turn.
