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Two aging crooks are given two weeks to repay a debt to a woman named The American. They recruit their recently deceased partner's son to help them break into a laboratory and steal the vaccine against STBO, a sexually transmitted disease that is sweeping the country. It's spread by having sex without emotional involvement, and most of its victims are teenagers who make love out of curiosity rather than commitment.
Emmanuelle, the sexiest woman in the world, endures a streak of bad luck that begins when she's stripped by a mob of adoring fans at an international film festival. Emmanuelle's lousy luck continues when she's abducted from her yacht off the South of France and forced to submit to the erotic desires of an Arab sheik.