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In the middle of a routine patrol, officer Daniel Carter happens upon a blood-soaked figure limping down a deserted stretch of road. He rushes the young man to a nearby rural hospital staffed by a skeleton crew, only to discover that patients and personnel are transforming into something inhuman. As the horror intensifies, Carter leads the other survivors on a hellish voyage into the subterranean depths of the hospital in a desperate bid to end the nightmare before it's too late.
While working undercover as a bodyguard to arms dealer Harry, former-soldier-turned-secret-service-agent Ewan survives a bloody shootout with a member of an Islamic terrorist cell who steals Harry's briefcase full of Semtex explosives and escapes. Ewan's spymasters task Ewan with hunting down the cell members and retrieving the briefcase.