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When his SUV breaks down on a remote Southwestern road, Jeff Taylor lets his wife, Amy, hitch a ride with a trucker to get help. When she doesn't return, Jeff fixes his SUV and tracks down the trucker -- who tells the police he's never seen Amy. Johnathan Mostow's tense thriller then follows Jeff's desperate search for his wife, which eventually uncovers a small town's murderous secret.
A young woman with no strong religious beliefs, Frankie Paige begins having strange and violent experiences, showing signs of the wounds that Jesus received when crucified. When the Vatican gets word of Frankie's situation, a high-ranking cardinal requests that the Rev. Andrew Kiernan investigate her case. Soon Kiernan realizes that very sinister forces are at work, and tries to rescue Frankie from the entity that is plaguing her.
