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A group of people find themselves trapped in the backwoods of West Virginia, fighting for their lives against a group of vicious and horribly disfigured inbred cannibals.
A westerner named Casey, studying Ninjutsu in Japan, is asked by the Sensei to return to New York to protect the legendary Yoroi Bitsu, an armored chest that contains the weapons of the last Koga Ninja.
Using fossilized DNA, a scientist resurrects one of nature's most fearsome predators, a sabretooth tiger. Scientific ambition turns deadly, however, when the creature escapes and begins savagely stalking its prey - the human race.
After a night of wild partying and missing their train, the group of students is invited to board another which happens to be heading their way. Once on board, members of the team begin to go missing, and their would-be saviors claim to have no idea what could have happened to them... When they discover the truth, it is too late to escape and they must fight for their lives against their captors to put an end to their ride to hell.
