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A somewhat daffy book editor on a rail trip from Los Angeles to Chicago thinks that he sees a murdered man thrown from the train. When he can find no one who will believe him, he starts doing some investigating of his own. But all that accomplishes is to get the killer after him.
Leonard Hoffman is an insurance salesman struggling to make ends meet. The fact that he has triplet sons who all want to go to Yale isn't making things any easier. Blanche Rickey is also worried about money; her husband is a millionaire with a weak heart, and she worries that he'll blow through all his cash before he finally dies. When Blanche meets Leonard, she devises a murderous plan that she claims will fix both their problems.
After her husband dies, Alice and her son, Tommy, leave their small New Mexico town for California, where Alice hopes to make a new life for herself as a singer. Money problems force them to settle in Arizona instead, where Alice takes a job as waitress in a small diner.
The sitcom takes us into the further adventures of the characters from the movie of the same name.