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Dong-gook, who is thinking of remarrying, introduces his stepmother Kyeong-sook to his son Jin-yeong. At the family gathering, Jin-yeong is surprised to see his stepmother's younger brother Hyeon-sook who was his one-night stand just a few days ago! Jin-yeong and his stepmother is lying down, drunk. Meanwhile, there is a strange atmosphere between Dong-gook and Hyeon-sook, who were drinking alone, and at that moment Jin-yeong's girlfriend Joo-yeon appears drunk.
Seo-ra, an elegant woman from Louisiana, U.S., marries businessman Kyeong-han who does anything to make money. Kyeong-hwan was in a relationship with Mi-yeon, who was a bar madam, but after his marriage to Seo-ra, he tells Mi-yeon that he will now live as an elegant businessman. For Kyeong-hwan, however, there was a problem of sexual desire and madness when he saw clothes with no underwear in sight. One day, Seo-ra's biological daughter Yoo-na, appeared at Kyeong-hwan's newlywed house in a short skirt.
Jini feels skeptical about her familiar life. A life you want to run away from. She has a crush on the newly entered boxer Doosan and asks to leave the place together. Doosan decides to stay there, contrary to Jini’s wishes. By the way…
Hyeong-woo is forced to be quarantined with her sisters-in-law for 21 days due to the new virus. Hyeong-woo, who remains with his sister-in-law is shaken by the temptation of prohibition. Eventually, the virus spreads and becomes the beginning of human extinction. However, rumors are circulating that sharing forbidden love can amplify the energy and defeat the new virus, which they cannot help but believe. Their own sex, which began like that, makes them forget even the fear of the virus and makes them unable to break up.