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The doctors find themselves simmering in a world of sexual politics. Bailey struggles with what it means to be a woman in charge of the hospital and her husband, while Maggie faces the challenges of dating a younger man and Amelia battles her own demons. Meanwhile, in the wake of a brutal attack, Meredith finds comfort and love in the most unexpected place, Callie and Arizona find themselves in a fight for their lives, and tensions run high when Amelia and Meredith come face to face with the doctor responsible for Derek's death.
